Awareness of adverse effects of Azathioprine in patients with Inflammatory Bowel Disease – more to be done?

نویسندگان

  • Andrew David Roy Spence
  • Regina Lee
  • D Keegan
  • GA Doherty
  • H Mulcahy
  • Seamus Murphy
چکیده

www.ums.ac.uk To determine what degree of causality rainfall, dry days and motorcycle events had on trauma incidence we used a Spearman rank co-efficient (SPC). We found poor correlation between the peaks of motorcycling accidents & other vehicle road accidents in both 2008 and 2009 (SPC 0.292 and 0.177 respectively). Motorcycling accidents are most common in months with most official motorcycle racing events (SPC 0.446 in 2008 and 0.888 in 2009). In both years, motorcycling RTA’s correlated strongly with temperature (SPC 0.692 and 0.743 respectively) while other vehicle RTA’s had a much weaker association with temperature (SPC 0.157 and 0.266 respectively). However dry days did not correlate inversely with motorbike accident incidence (SPC 0.385 in 2008 and -0.142 in 2009).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of low doses of Azathioprine in reducing relapse and corticosteroid dependence in patients with Ulcerative Colitis

Background and Aim: Ulcerative Colitis is an idiopathic inflammatory bowel disease that is common in adults. Although corticosteroids are the most effective preservative treatment for Ulcerative Colitis. However, due to the dependence of these drugs and their serious complications, the use of an immunosuppressive drug or surgery should be taken seriously. Thus the aim of the study was the evalu...

متن کامل

Neonatal Presentation of Unremitting Inflammatory Bowel Disease

Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...

متن کامل

Dapsone as a second glucocorticoid-sparing agent in addition to azathioprine in treatment of pemphigus vulgaris

Background and aim: Pemphigus vulgaris is an autoimmune vesiculobullous disorder. Prior to the advent of glucocorticoid therapy, it was often fatal. Now its mortality and morbidity is due to highdose glucocorticoid complications rather than the disease itself. This study was aimed to determine the effect of dapsone as a second adjuvant in the treatment of pemphigus vulgaris.Materials and method...

متن کامل

Adverse Events Associated with Azathioprine Treatment in Korean Pediatric Inflammatory Bowel Disease Patients

PURPOSE This study was aimed to evaluate the frequency and course of adverse events associated with azathioprine treatment in Korean pediatric patients with inflammatory bowel disease. METHODS Total of 174 pediatric patients (age range, 1 to 19 years) with inflammatory bowel disease who received azathioprine in order to maintain remission at Samsung Medical Center (Seoul, Korea) from January ...

متن کامل

Comparison of Coping Strategies in People with Inflammatory Bowel Disease and Healthy People in Terms of Health Locus of Control

Background: Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation (pain and swelling) in the intestines. IBD includes Crohn’s disease and ulcerative colitis. Both types affect the digestive system. The study aims to compare coping strategies in people with inflammatory bowel disease and healthy people, according to internal and external sources of health contr...

متن کامل

Azathioprine in inflammatory bowel disease, a safe alternative?

Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects occur in about 15% of patients. The main side effects are pancreatitis, allergic reactions, fever and bo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 83  شماره 

صفحات  -

تاریخ انتشار 2014